姓名:余绍宁
联系地址:宁波大学包玉书7号楼304室
电子邮件:yushaoning@daohangbc.com
个人基本信息:复旦大学化学系学士、硕士;中国科学院应用物理所博士。曾在美国德克萨斯大学医学分校、哈佛大学医学院做博士后,耶鲁大学访问教授。1990.07-2001.02任职海军医学研究所助理研究员及副研究员;2005.09 -2019.10复旦大学化学系任教授、博士生导师。2019.10以“学术领军人物”引至宁波大学。
研究领域:1)蛋白质结构领域:用光谱技术研究结合纳米材料后蛋白质结构或构象的变化,以阐述纳米粒子作为药物或药物载体对所结合蛋白结构及其功能的影响;研究一些蛋白药物或其他功能蛋白在其他相关分子作用下的结构或构象变化以及所产生的生理影响; 2)微生物领域:用红外光谱、质谱方法研究微生物的分类和分型,特定领域微生物质谱和红外数据库的建立;研究复杂条件下微生物捕获的新方法和技术;应用拉曼增强光谱在微生物分析鉴定中的应用; 3)临床检验技术:研究各种肿瘤的血清质谱鉴定方法;对一些临床疾病检测方法进行完善和新方法的研究。
研究项目:先后承担多项国家自然科学基金委员会重点项目、国家科技部重大研究计划项目、国家科技部973项目分题、上海市人才基金项目等。
研究成果:
1. Shi, H., Sun, J., Han, R., Ding, C., Hu, F., & Yu, S. (2020). The strategy for correcting interference from water in Fourier transform infrared spectrum based bacterial typing. Talanta, 208, 120347.
2. Qiaoyu Li, Yanlin Wang, Guopeng Yu, Yushan Liu, Keqi Tang, Chuanfan Ding, Hui Chen*, and Shaoning Yu*. An “off-on” type biosensor based on polymer dots-labeled peptide and graphene oxide for Metalloproteinase-9 detection. Nanoscale, 2020, in press.
3. Jiaojiao Sun, Haimei Shi, Tianlu Mo, Yinlu Zhang, Xudong Wang, Chuanfan Ding*, and Shaoning Yu*. Protein binding on the surface of magnetic nanoparticles.Partcle, 2019, 1900072.
4. Xiaoning Zhang, Haimei Shi, Rutan Zhang, Junting Zhang, and Shaoning Yu*.The Competitive Dynamic Binding of Some Plasma Proteins Adsorbed on Gold Nanoparticles.Partcle, 2018, 1800257.
5. Xiaoning Zhang, Junting Zhang, Fan Zhang, and Shaoning Yu*. Probing the Binding Affinity of Plasma Proteins Adsorbed on Au Nanoparticles Nanoscale, 2017, 9, 4787-4792.
6. Mengmeng Wang, Cuiping Fu, Xingang Liu, Zhipeng Lin, Ning Yang and Shaoning Yu*.Probing the Mechanism of Plasma Proteins Adsorption on Au and Ag Nanoparticles with FT-IR Spectroscopy.Nanoscale, 2015, 7, 15191-15196.
7. Huayan Yang, Shouning Yang, Jilie Kong, Aichun Dong* &Shaoning Yu*. Obtaining information about protein secondary structures in aqueous solution using Fourier transform IR spectroscopy. Nature Protocols, 10(3):382-396, 2015.
8. Cuiping Fu, Huayan Yang, Mengmeng Wang, HuanmingXiong and Shaoning Yu*. Serum albumin adsorbed on Au nanoparticles: structural changes over time induced by S–Au interaction. Chem. Commun., 51:3634-3636, 2015.
9. Shaoning Yu*, Rodrigo A. Maillard, Alexey V. Gribenko, and J. Ching Lee* Local Control of the N-Capping Propensities of the D-Helix; Global Effects on Allostery in E. coli cAMP Receptor Protein. J. Biol. Chem. 2012, 287, 39402-39411.
10.Kong, J., & Yu, S. Fourier transform infrared spectroscopic analysis of protein secondary structures. ActabiochimicaetbiophysicaSinica, 2007, 39(8), 549-559.