Time: 9:30am, April 23, 2024

Location：Room 227, No.1 Laboratory Building, North District, School of Materials and Chemistry

Lecturer:Prof. Fu Zhifeng

Abstract:Rapid, efficient and sensitive detection of disease-causing bacteria plays an important role in disease diagnosis, bioterrorism, food and drinking water safety, and is of great significance in safeguarding people's health, economic development and national security. For common pathogenic bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacter baumannii, a series of new methods of chemiluminescence and fluorescence detection for pathogenic bacteria have been established by utilizing the specific recognition effect of potent phage and its functional proteins on host bacteria. The in vitro antibacterial effect of phage endolysin proteins on super-resistant bacteria was also studied, and its efficient therapeutic effect on drug-resistant bacterial infections was confirmed in animal models, which provided a preliminary basis for the research and development of subsequent protein-based antibacterial drugs.